Prevailing homozygous deletion of interferon and defensin genes in human cancers
نویسندگان
چکیده
Division of Biomedical Statistics and Informatics, Department of Health Sciences, Mayo Clinic, Rochester, Minnesota, United States of America Department of Immunology, College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America Department of Urology, Mayo Clinic, Rochester, Minnesota, United States of America Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
منابع مشابه
Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers.
Cytogenetic analyses of non-small cell lung cancer have revealed deletions of the short arm of chromosome 9 with breakpoints at 9p11-pter in a significant proportion of tumors. Recent evidence suggests that homozygous loss of the interferon (IFN) and methylthioadenosine phosphorylase (MTAP) genes located on 9p and a tumor suppressor gene closely linked to them is associated with acute lymphobla...
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